DMG and Autism- Does DMG have an impact on Behavioral Challenges?

Dimethyglycine (DMG) is an amino acid that is an essential part of the metabolic pathway. It’s so important because it’s a one-carbon-donator that directly affects the methylation pathways, the immune system, and detoxification pathways.


Methylation plays a role in many conditions, and it impacts a wide range of factors that help to establish what functional medical practitioners consider good health and well being. DMG supports methylation.

Immunological Imbalances

Many children with behavioral challenges suffer from immunological imbalances. Their bodies often have trouble dealing with invaders that other children may handle more easily. Behaviorally challenged kids seem to have an impaired ability to develop a robust immune ability to develop a robust immune system. A number of published studies have shown DMG to enhance antibody production (B Cells) as well as T Cells, which produce specific protein molecules that help keep the immune system strong an defend the body from outside invaders.

Detoxification & Healthy Inflammation Benefits

One of the most well-known factors that lead to behavioral challenges is exposure to environmental toxins. Heavy metals, pesticides, and chlorinated hydrocarbons are linked to major cognitive and neurological issues along with inflammation and a weakened immune system.

DMG supports a healthy pathway that helps isolate free radicals. On top of that, DMG is one of the principal building blocks for the production of glutathione. The liver produces glutathione as one of the body’s primary detoxifying agents and antioxidants. DMG also helps increase oxygenation and reduces levels of lactic acid. These are all factors that contribute to a variety of challenges.

DMG is a biomedical intervention, but sometimes the body just isn’t producing enough of it. Under these circumstances, providing DMG as a supplement can help the patient reap the benefits and biomedical enhancements that adequate levels of this particular amino acid impart.

DMG contributes to many health improvements and is extremely effective at improving methylation, the immune system, and detoxification.

DMG and the GI Tract

Gut issues and GI tract impairment are affected by diet and other external factors. Heavy metals are also factors, and they’re constant issue for the body, found in a number of lurches. Because gut dysfunction is often a result of a partially blocked methylation process, DMG can help to balance GI tract issues. Additionally, the detoxification and glutathione support it provides can help the body reduce its levels of heavy metals and environmental chemicals.

DMG doesn’t work alone. It is a precursor to SAM-e, and there are some enzymes, vitamins, and cofactors such as Vitamin B12 and folic acid which help transfer the methyl groups to SAM-e. So if the patient is deficient in any of these lateral areas supplementing with DMG could cause Dimethlglycine to build up and result in other imbalances.

DMG can help behavioral challenges by supporting:

  • Vocal Communication
  • Social Skills
  • Eye Contact
  • Improved quality sleep
  • Focus and Calm

It doesn’t take a long time for patients to see positive results. DMG often begins working in days, not weeks. DMG has been shown to be particularly helpful with symptoms such as repetitive behavior and improve communication skills. In fact, studies done by Dr. Rimland showed that 45% of 6000 patients who gave their children DMG supplements reported significant improvements.

When you consider how complex behavioral challenges are, and how many different things an contribute to its array of symptoms, significant improvements in nearly half of all patients is an astounding number.

DMG supplementation isn’t going to work for every patient. But it is something that practitioners can test with a trial period. If it doesn’t work, they can still utilize this information to create a plan that works for that specific child- the problem causing the symptoms may not be related to the methylation pathways. However, if the problem does have to Dow it’s methylation, DMG and adjacent supplementation may provide significant benefits to the patient.

Posted by Dr. Roger Kendall Apr 24, 2019 DaVinci Labs Blog

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